There has been a trend over recent years for combining a nonsteroidal antiinflammatory drug (NSAID) with paracetamol (acetaminophen) for pain management. However, therapeutic superiority of the combination of paracetamol and an NSAID over either drug alone remains controversial.
A new systematic review has been published involving 20s RCTs and 1852 patients compared paracetamol/NSAID combinations with paracetamol alone.
In 16 studies (80%), an analgesic combination was more effective than acetaminophen alone for at least one of three measures of the following:
- pain score
- need for supplemental analgesia
- globally assessed pain relief).
The mean reduction in pain intensity was 35%, and the mean reduction in need for supplemental analgesics was 39%.
Click here for Journal Watch commentary.
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